Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM50320054
Substrate
n/a
Meas. Tech.
ChEMBL_635108 (CHEMBL1119418)
IC50
11.5±n/a nM
Citation
Chen, JC; Uang, BJ; Lyu, PC; Chang, JY; Liu, KJ; Kuo, CC; Hsieh, HP; Wang, HC; Cheng, CS; Chang, YH; Chang, MD; Chang, WS; Lin, CC Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. J Med Chem 53:4545-9 (2010) [PubMed] Article
More Info.:
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Inhibitor
Name:
BDBM50320054
Synonyms:
CHEMBL1085977 | ethyl 2-((S)-4-(benzyloxy)-3-((S)-3-cyclohexyl-2-(2,5-difluorobenzamido)propanamido)-2-oxobutanamido)acetate
Type:
Small organic molecule
Emp. Form.:
C31H37F2N3O7
Mol. Mass.:
601.6382
SMILES:
CCOC(=O)CNC(=O)C(=O)[C@H](COCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)c1cc(F)ccc1F |r|