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Target
Kappa-type opioid receptor
Ligand
BDBM50320087
Substrate
n/a
Meas. Tech.
ChEMBL_635250 (CHEMBL1118190)
IC50
>1000±n/a nM
Citation
 Nagase, H; Imaide, S; Tomatsu, M; Nemoto, T; Nakajima, M; Nakao, K; Mochizuki, H; Fujii, H Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology. Bioorg Med Chem Lett 20:3726-9 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50320087
Synonyms:
(2R,2aS,2a1S,5aR)-2a,7-dihydroxy-2-(methylamino)-2,2a,2a1,3,4,5a-hexahydrophenanthro[4,5-bcd]furan-5(1H)-one | CHEMBL1082638
Type:
Small organic molecule
Emp. Form.:
C15H17NO4
Mol. Mass.:
275.2998
SMILES:
CN[C@@H]1Cc2ccc(O)c3O[C@@H]4[C@H](c23)[C@@]1(O)CCC4=O |r|
Structure:
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