Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM50320090
Substrate
n/a
Meas. Tech.
ChEMBL_635250 (CHEMBL1118190)
Ki
5.1±n/a nM
Citation
 Nagase, H; Imaide, S; Tomatsu, M; Nemoto, T; Nakajima, M; Nakao, K; Mochizuki, H; Fujii, H Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology. Bioorg Med Chem Lett 20:3726-9 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50320090
Synonyms:
(2R,2aS,2a1S,5aR)-2-((cyclopropylmethyl)(methyl)amino)-2a,7-dihydroxy-2,2a,2a1,3,4,5a-hexahydrophenanthro[4,5-bcd]furan-5(1H)-one | CHEMBL1082968
Type:
Small organic molecule
Emp. Form.:
C19H23NO4
Mol. Mass.:
329.3902
SMILES:
CN(CC1CC1)[C@@H]1Cc2ccc(O)c3O[C@@H]4[C@H](c23)[C@@]1(O)CCC4=O |r|
Structure:
Search PDB for entries with ligand similarity: