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Target
Kappa-type opioid receptor
Ligand
BDBM50320091
Substrate
n/a
Meas. Tech.
ChEMBL_635250 (CHEMBL1118190)
IC50
>1000±n/a nM
Citation
 Nagase, H; Imaide, S; Tomatsu, M; Nemoto, T; Nakajima, M; Nakao, K; Mochizuki, H; Fujii, H Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology. Bioorg Med Chem Lett 20:3726-9 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50320091
Synonyms:
(1R,5S,10R,18S)-9-(cyclopropylmethyl)-15-hydroxy-6,19-dioxa-9-azapentacyclo[14.2.1.0^{5,10}.0^{5,18}.0^{12,17}]nonadeca-12(17),13,15-trien-2-one | CHEMBL1082969
Type:
Small organic molecule
Emp. Form.:
C20H23NO4
Mol. Mass.:
341.4009
SMILES:
Oc1ccc2C[C@H]3N(CC4CC4)CCO[C@]33CCC(=O)[C@@H]4Oc1c2[C@H]34 |r|
Structure:
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