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Target
Bcl-2-like protein 1
Ligand
BDBM50321033
Substrate
n/a
Meas. Tech.
ChEMBL_639438 (CHEMBL1168411)
IC50
220000±n/a nM
Citation
 Leverrier, A; Martin, MT; Servy, C; Ouazzani, J; Retailleau, P; Awang, K; Mukhtar, MR; Guéritte, F; Litaudon, M Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus. J Nat Prod 73:1121-5 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50321033
Synonyms:
CHEMBL1165508 | ent-17-Hydroxytrachyloban-18-oic acid
Type:
Small organic molecule
Emp. Form.:
C20H30O3
Mol. Mass.:
318.4504
SMILES:
C[C@]12CCC[C@](C)([C@@H]1CC[C@]13C[C@@H]4[C@H](C[C@@H]21)[C@]4(CO)C3)C(O)=O |r|
Structure:
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