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Target
Polyphenol oxidase 2
Ligand
BDBM50321284
Substrate
n/a
Meas. Tech.
ChEMBL_638417 (CHEMBL1167863)
IC50
>100000±n/a nM
Citation
 Koyama, K; Hirasawa, Y; Hosoya, T; Hoe, TC; Chan, KL; Morita, H Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora. Bioorg Med Chem 18:4415-21 (2010) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50321284
Synonyms:
Alpneumine F | CHEMBL1165402
Type:
Small organic molecule
Emp. Form.:
C20H22N2O4
Mol. Mass.:
354.3997
SMILES:
COC(=O)[C@@]12CO[C@]3(O)[C@H]4CCN(CC[C@@H]13)[C@H]4c1c2[nH]c2ccccc12 |r,TLB:8:7:16:11.10,THB:4:15:16:11.10,6:7:16:11.10,14:15:5.6:18.17.9.16|
Structure:
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