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Target
UDP-glucose 4-epimerase
Ligand
BDBM60209
Substrate
n/a
Meas. Tech.
ChEMBL_642050 (CHEMBL1176082)
IC50
3600±n/a nM
Citation
 Durrant, JD; Urbaniak, MD; Ferguson, MA; McCammon, JA Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem 53:5025-32 (2010) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
UDP-galactose 4-epimerase
Type:
PROTEIN
Mol. Mass.:
43523.37
Organism:
Trypanosoma brucei
Description:
ChEMBL_642050
Residue:
395
Sequence:
MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYASQENGTPGGRTTKL
  
Inhibitor
Name:
BDBM60209
Synonyms:
2-[2-[(6-keto-5H-phenanthridin-3-yl)carbamoyl]phenyl]benzoic acid | 2-[2-[(6-oxidanylidene-5H-phenanthridin-3-yl)carbamoyl]phenyl]benzoic acid | 2-[2-[(6-oxo-5H-phenanthridin-3-yl)carbamoyl]phenyl]benzoic acid | 2-[2-[oxo-[(6-oxo-5H-phenanthridin-3-yl)amino]methyl]phenyl]benzoic acid | CHEMBL1172911 | MLS000737579 | SMR000528568 | cid_278037
Type:
Small organic molecule
Emp. Form.:
C27H18N2O4
Mol. Mass.:
434.4428
SMILES:
OC(=O)c1ccccc1-c1ccccc1C(=O)Nc1ccc2c(c1)[nH]c(=O)c1ccccc21
Structure:
Search PDB for entries with ligand similarity: