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Target
UDP-glucose 4-epimerase
Ligand
BDBM50322670
Substrate
n/a
Meas. Tech.
ChEMBL_642050 (CHEMBL1176082)
IC50
3800±n/a nM
Citation
 Durrant, JD; Urbaniak, MD; Ferguson, MA; McCammon, JA Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem 53:5025-32 (2010) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
UDP-galactose 4-epimerase
Type:
PROTEIN
Mol. Mass.:
43523.37
Organism:
Trypanosoma brucei
Description:
ChEMBL_642050
Residue:
395
Sequence:
MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYDTLEAIMETSWKFQRTHPNGYASQENGTPGGRTTKL
  
Inhibitor
Name:
BDBM50322670
Synonyms:
2'-(7-fluoro-9H-fluoren-2-ylcarbamoyl)biphenyl-2-carboxylic acid | CHEMBL1173453
Type:
Small organic molecule
Emp. Form.:
C27H18FNO3
Mol. Mass.:
423.4351
SMILES:
OC(=O)c1ccccc1-c1ccccc1C(=O)Nc1ccc-2c(Cc3cc(F)ccc-23)c1
Structure:
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