Reaction Details Report a problem with these data
Target
Neuropeptide S receptor
Ligand
BDBM50322842
Substrate
n/a
Meas. Tech.
ChEMBL_644490 (CHEMBL1211328)
IC50
18±n/a nM
Citation
 Melamed, JY; Zartman, AE; Kett, NR; Gotter, AL; Uebele, VN; Reiss, DR; Condra, CL; Fandozzi, C; Lubbers, LS; Rowe, BA; McGaughey, GB; Henault, M; Stocco, R; Renger, JJ; Hartman, GD; Bilodeau, MT; Trotter, BW Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists. Bioorg Med Chem Lett 20:4700-3 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50322842
Synonyms:
CHEMBL1210177 | N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1-(4-methylpiperazin-1-yl)cyclohexyl)methyl)cyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C30H44N4O2
Mol. Mass.:
492.696
SMILES:
CN1CCN(CC1)C1(CN(Cc2cc3ccccc3n(C)c2=O)C(=O)C2CCCCC2)CCCCC1
Structure:
Search PDB for entries with ligand similarity: