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Target
B1 bradykinin receptor
Ligand
BDBM50322870
Substrate
n/a
Meas. Tech.
ChEMBL_644657 (CHEMBL1211636)
IC50
1.3±n/a nM
Citation
 Liu, Q; Qian, W; Li, A; Biswas, K; Chen, JJ; Fotsch, C; Han, N; Yuan, C; Arik, L; Biddlecome, G; Johnson, E; Kumar, G; Lester-Zeiner, D; Ng, GY; Hungate, RW; Askew, BC Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists. Bioorg Med Chem Lett 20:4593-7 (2010) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50322870
Synonyms:
(R)-3-(4-fluorophenyl)-N-((R)-6-(3-(pyrrolidin-1-yl)prop-1-en-2-yl)-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(3-(trifluoromethyl)phenylsulfonamido)propanamide | CHEMBL1210756
Type:
Small organic molecule
Emp. Form.:
C33H35F4N3O3S
Mol. Mass.:
629.708
SMILES:
Fc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCCc2cc(ccc12)C(=C)CN1CCCC1)NS(=O)(=O)c1cccc(c1)C(F)(F)F |r|
Structure:
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