Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50324677
Substrate
n/a
Meas. Tech.
ChEMBL_653532 (CHEMBL1226735)
Ki
4630±n/a nM
Citation
 Sanna, MG; Wang, SK; Gonzalez-Cabrera, PJ; Don, A; Marsolais, D; Matheu, MP; Wei, SH; Parker, I; Jo, E; Cheng, WC; Cahalan, MD; Wong, CH; Rosen, H Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol 2:434-41 (2006) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50324677
Synonyms:
(S)-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid | CHEMBL1221650
Type:
Small organic molecule
Emp. Form.:
C16H27N2O4P
Mol. Mass.:
342.3703
SMILES:
CCCCCCc1cccc(NC(=O)[C@@H](N)CCP(O)(O)=O)c1 |r|
Structure:
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