Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50324990
Substrate
n/a
Meas. Tech.
ChEMBL_651582 (CHEMBL1227965)
Ki
460±n/a nM
Citation
 Sams, AG; Mikkelsen, GK; Larsen, M; Torup, L; Brennum, LT; Schrøder, TJ; Bang-Andersen, B Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists. Bioorg Med Chem Lett 20:5241-4 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50324990
Synonyms:
CHEMBL1221508 | N-[5-(2-Ethyl-2H-tetrazol-5-yl)-4-phenyl-thiazol-2-yl]-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C20H18N6OS
Mol. Mass.:
390.462
SMILES:
CCn1nnc(n1)-c1sc(NC(=O)Cc2ccccc2)nc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: