Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50324990
Substrate
n/a
Meas. Tech.
ChEMBL_651580 (CHEMBL1227963)
Ki
1200±n/a nM
Citation
 Sams, AG; Mikkelsen, GK; Larsen, M; Torup, L; Brennum, LT; Schrøder, TJ; Bang-Andersen, B Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists. Bioorg Med Chem Lett 20:5241-4 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50324990
Synonyms:
CHEMBL1221508 | N-[5-(2-Ethyl-2H-tetrazol-5-yl)-4-phenyl-thiazol-2-yl]-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C20H18N6OS
Mol. Mass.:
390.462
SMILES:
CCn1nnc(n1)-c1sc(NC(=O)Cc2ccccc2)nc1-c1ccccc1
Structure:
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