Reaction Details Report a problem with these data
Target
Cholesteryl ester transfer protein
Ligand
BDBM50325127
Substrate
n/a
Meas. Tech.
ChEMBL_651690 (CHEMBL1228380)
IC50
30000±n/a nM
Citation
 Ling, C; Zheng, Z; Jiang, XC; Zhong, W; Li, S Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors. Bioorg Med Chem Lett 20:5123-5 (2010) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50325127
Synonyms:
CHEMBL1222598 | N-(5-benzyl-4-(4-methoxyphenyl)-1,3-selenazol-2-yl)-3,4-dimethoxybenzamide
Type:
Small organic molecule
Emp. Form.:
C26H24N2O4Se
Mol. Mass.:
507.44
SMILES:
COc1ccc(cc1)-c1nc(NC(=O)c2ccc(OC)c(OC)c2)[se]c1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: