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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50325156
Substrate
n/a
Meas. Tech.
ChEMBL_651698 (CHEMBL1228388)
IC50
50±n/a nM
Citation
 Oza, V; Ashwell, S; Brassil, P; Breed, J; Deng, C; Ezhuthachan, J; Haye, H; Horn, C; Janetka, J; Lyne, P; Newcombe, N; Otterbien, L; Pass, M; Read, J; Roswell, S; Su, M; Toader, D; Yu, D; Yu, Y; Valentine, A; Webborn, P; White, A; Zabludoff, S; Zheng, X Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration. Bioorg Med Chem Lett 20:5133-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50325156
Synonyms:
8-(4-hydroxy-3-methylphenyl)-5-methyl-[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one | CHEMBL1223247
Type:
Small organic molecule
Emp. Form.:
C18H15N3O2
Mol. Mass.:
305.3306
SMILES:
Cc1cc(ccc1O)-c1ccc2c(C)cc3n[nH]c(=O)n3c2c1
Structure:
Search PDB for entries with ligand similarity: