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Target
Kappa-type opioid receptor
Ligand
BDBM50325526
Substrate
n/a
Meas. Tech.
ChEMBL_652217 (CHEMBL1228490)
Ki
0.935±n/a nM
Citation
 Fujii, H; Ida, Y; Hanamura, S; Osa, Y; Nemoto, T; Nakajima, M; Hasebe, K; Nakao, K; Mochizuki, H; Nagase, H Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. Bioorg Med Chem Lett 20:5035-8 (2010) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50325526
Synonyms:
CHEMBL1223773
Type:
Small organic molecule
Emp. Form.:
C34H36N2O4
Mol. Mass.:
536.6606
SMILES:
Cn1c(C=CC(=O)CCc2ccccc2)cc2C[C@@]3(O)[C@H]4Cc5ccc(O)c6O[C@@H](c12)[C@]3(CCN4CC1CC1)c56 |r,w:3.2|
Structure:
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