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Target
Guanine deaminase
Ligand
BDBM7957
Substrate
n/a
Meas. Tech.
ChEMBL_652430 (CHEMBL1225633)
Ki
4440±n/a nM
Citation
 Fernández, JR; Sweet, ES; Welsh, WJ; Firestein, BL Identification of small molecule compounds with higher binding affinity to guanine deaminase (cypin) than guanine. Bioorg Med Chem 18:6748-55 (2010) [PubMed]  Article 
Target
Name:
Guanine deaminase
Synonyms:
GAH | GDA | GUAD_HUMAN | Guanase | Guanine aminase | Guanine aminohydrolase | KIAA1258 | p51-nedasin
Type:
PROTEIN
Mol. Mass.:
50993.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885179
Residue:
454
Sequence:
MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV
  
Inhibitor
Name:
BDBM7957
Synonyms:
4-amino-1H-imidazole-5-carboxamide | 5-Amino-3H-imidazole-4-carboxylic acid amide | Imidazole C-4,5 deriv. 2
Type:
Small organic molecule
Emp. Form.:
C4H6N4O
Mol. Mass.:
126.1166
SMILES:
NC(=O)c1[nH]cnc1N
Structure:
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