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Target
Cannabinoid receptor 1
Ligand
BDBM50325890
Substrate
n/a
Meas. Tech.
ChEMBL_652678 (CHEMBL1225881)
IC50
3±n/a nM
Citation
 Letourneau, JJ; Jokiel, P; Olson, J; Riviello, CM; Ho, KK; McAleer, L; Yang, J; Swanson, RN; Baker, J; Cowley, P; Edwards, D; Ward, N; Ohlmeyer, MH; Webb, ML Identification and hit-to-lead optimization of a novel class of CB1 antagonists. Bioorg Med Chem Lett 20:5449-53 (2010) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50325890
Synonyms:
CHEMBL1224536 | N-(1-((6-(benzo[d][1,3]dioxol-4-yl)pyridin-2-yl)methyl)-1H-indol-6-yl)-3-hydroxy-3-methylbutanamide
Type:
Small organic molecule
Emp. Form.:
C26H25N3O4
Mol. Mass.:
443.4944
SMILES:
CC(C)(O)CC(=O)Nc1ccc2ccn(Cc3cccc(n3)-c3cccc4OCOc34)c2c1
Structure:
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