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Target
Tumor necrosis factor receptor superfamily member 5
Ligand
BDBM50325995
Substrate
n/a
Meas. Tech.
ChEMBL_660437 (CHEMBL1250027)
IC50
50±n/a nM
Citation
 Fournel, S; Wieckowski, S; Sun, W; Trouche, N; Dumortier, H; Bianco, A; Chaloin, O; Habib, M; Peter, JC; Schneider, P; Vray, B; Toes, RE; Offringa, R; Melief, CJ; Hoebeke, J; Guichard, G C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L. Nat Chem Biol 1:377-82 (2005) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 5
Synonyms:
B-cell surface antigen CD40 | Bp50 | CD40 | CD40L receptor | CD_antigen=CD40 | CDw40 | TNFRSF5 | TNR5_HUMAN
Type:
PROTEIN
Mol. Mass.:
30614.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_660437
Residue:
277
Sequence:
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
  
Inhibitor
Name:
BDBM50325995
Synonyms:
(2S,2'S,2''S)-N,N',N''-((4S,4'S,4''S,7S,7'S,7''S)-20,20',20''-((2S,5S,10S)-7,12-dioxo-1,4,8-triazacyclododecane-2,5,10-triyl)tris(4,7-bis(4-hydroxybenzyl)-2,5,8,15-tetraoxo-3'',6'',9'',16''-tetraazaicosane-20,1-diyl))tris(2,6-diaminohexanamide) | CHEMBL1241018
Type:
Small organic molecule
Emp. Form.:
C117H176N24O23
Mol. Mass.:
2286.7963
SMILES:
NCCCC[C@H](N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCC(=O)NCCCC[C@@H]1CNC(=O)C[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@@H](N)CCCCN)NC[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CNC(=O)[C@@H](N)CCCCN)NC(=O)C1 |r|
Structure:
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