Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 5
Ligand
BDBM50325996
Substrate
n/a
Meas. Tech.
ChEMBL_660437 (CHEMBL1250027)
IC50
9900±n/a nM
Citation
 Fournel, S; Wieckowski, S; Sun, W; Trouche, N; Dumortier, H; Bianco, A; Chaloin, O; Habib, M; Peter, JC; Schneider, P; Vray, B; Toes, RE; Offringa, R; Melief, CJ; Hoebeke, J; Guichard, G C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L. Nat Chem Biol 1:377-82 (2005) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 5
Synonyms:
B-cell surface antigen CD40 | Bp50 | CD40 | CD40L receptor | CD_antigen=CD40 | CDw40 | TNFRSF5 | TNR5_HUMAN
Type:
PROTEIN
Mol. Mass.:
30614.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_660437
Residue:
277
Sequence:
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLRVQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIATGVSDTICEPCPVGFFSNVSSAFEKCHPWTSCETKDLVVQQAGTNKTDVVCGPQDRLRALVVIPIIFGILFAILLVLVFIKKVAKKPTNKAPHPKQEPQEINFPDDLPGSNTAAPVQETLHGCQPVTQEDGKESRISVQERQ
  
Inhibitor
Name:
BDBM50325996
Synonyms:
CHEMBL1241019 | N1-((5S,11S,14S,44S,47S,53S)-1,5,53,57-tetraamino-29-((15S,18S,24S)-24,28-diamino-15,18-bis(4-hydroxybenzyl)-7,14,17,20,23-pentaoxo-2-oxa-6,13,16,19,22-pentaazaoctacosyl)-11,14,44,47-tetrakis(4-hydroxybenzyl)-6,9,12,15,22,36,43,46,49,52-decaoxo-27,31-dioxa-7,10,13,16,23,35,42,45,48,51-decaazaheptapentacontan-29-yl)succinamide
Type:
Small organic molecule
Emp. Form.:
C113H169N23O26
Mol. Mass.:
2265.6895
SMILES:
NCCCC[C@H](N)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCC(=O)NCCCOCC(COCCCNC(=O)CCCCCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](N)CCCCN)(COCCCNC(=O)CCCCCNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@@H](N)CCCCN)NC(=O)CCC(N)=O |r|
Structure:
Search PDB for entries with ligand similarity: