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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50326013
Substrate
n/a
Meas. Tech.
ChEMBL_654656 (CHEMBL1243700)
IC50
25000±n/a nM
Citation
 Love, KR; Catic, A; Schlieker, C; Ploegh, HL Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol 3:697-705 (2007) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50326013
Synonyms:
3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)indolin-2-one | CHEMBL1241673
Type:
Small organic molecule
Emp. Form.:
C17H11BrCl2N2O3
Mol. Mass.:
442.091
SMILES:
CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Br)cc12 |w:4.3|
Structure:
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