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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM53421
Substrate
n/a
Meas. Tech.
ChEMBL_654656 (CHEMBL1243700)
IC50
600±n/a nM
Citation
 Love, KR; Catic, A; Schlieker, C; Ploegh, HL Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol 3:697-705 (2007) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM53421
Synonyms:
4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2-phenylquinazoline | MLS001049987 | Menadione, 11 | SMR000469604 | cid_23640938
Type:
Small organic molecule
Emp. Form.:
C20H20N2
Mol. Mass.:
288.3862
SMILES:
C1CCC(CC1)c1nc(nc2ccccc12)-c1ccccc1
Structure:
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