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Target
Cathepsin L2
Ligand
BDBM12311
Substrate
n/a
Meas. Tech.
ChEMBL_656007 (CHEMBL1245051)
IC50
75±n/a nM
Citation
 Liverton, NJ; Carroll, SS; Dimuzio, J; Fandozzi, C; Graham, DJ; Hazuda, D; Holloway, MK; Ludmerer, SW; McCauley, JA; McIntyre, CJ; Olsen, DB; Rudd, MT; Stahlhut, M; Vacca, JP MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother 54:305-11 (2009) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM12311
Synonyms:
(1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide | 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide | BOCEPREVIR | SCH 503034 | acs.jmedchem.1c00409_ST.355
Type:
Small organic molecule
Emp. Form.:
C27H45N5O5
Mol. Mass.:
519.6767
SMILES:
CC(C)(C)NC(=O)N[C@H](C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)NC(CC1CCC1)C(=O)C(N)=O)C2(C)C)C(C)(C)C |r|
Structure:
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