Reaction Details Report a problem with these data
Target
Enoyl-acyl carrier reductase ENR
Ligand
BDBM50326321
Substrate
n/a
Meas. Tech.
ChEMBL_657369 (CHEMBL1246345)
IC50
>2000±n/a nM
Citation
 Tipparaju, SK; Muench, SP; Mui, EJ; Ruzheinikov, SN; Lu, JZ; Hutson, SL; Kirisits, MJ; Prigge, ST; Roberts, CW; Henriquez, FL; Kozikowski, AP; Rice, DW; McLeod, RL Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J Med Chem 53:6287-300 (2010) [PubMed]  Article 
Target
Name:
Enoyl-acyl carrier reductase ENR
Synonyms:
Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:
PROTEIN
Mol. Mass.:
43663.67
Organism:
Toxoplasma gondii
Description:
ChEMBL_1290812
Residue:
417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSSSSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
  
Inhibitor
Name:
BDBM50326321
Synonyms:
CHEMBL1243085 | Hexa-2,4-dienoic Acid(4-(4-Chloro-2-hydroxyphenoxy)-phenyl)amide
Type:
Small organic molecule
Emp. Form.:
C18H16ClNO3
Mol. Mass.:
329.778
SMILES:
C\C=C\C=C\C(=O)Nc1ccc(Oc2ccc(Cl)cc2O)cc1
Structure:
Search PDB for entries with ligand similarity: