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Target
Enoyl-acyl carrier reductase ENR
Ligand
BDBM50326325
Substrate
n/a
Meas. Tech.
ChEMBL_657369 (CHEMBL1246345)
IC50
>20000±n/a nM
Citation
 Tipparaju, SK; Muench, SP; Mui, EJ; Ruzheinikov, SN; Lu, JZ; Hutson, SL; Kirisits, MJ; Prigge, ST; Roberts, CW; Henriquez, FL; Kozikowski, AP; Rice, DW; McLeod, RL Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J Med Chem 53:6287-300 (2010) [PubMed]  Article 
Target
Name:
Enoyl-acyl carrier reductase ENR
Synonyms:
Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:
PROTEIN
Mol. Mass.:
43663.67
Organism:
Toxoplasma gondii
Description:
ChEMBL_1290812
Residue:
417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSSSSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
  
Inhibitor
Name:
BDBM50326325
Synonyms:
1-(2-chloro-4-nitrobenzyl)-4-(benzyloxy)pyridin-2(1H)-one | 4-(benzyloxy)-1-(2-chloro-4-nitrobenzyl)pyridin-2(1H)-one | CHEMBL260771
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O4
Mol. Mass.:
370.786
SMILES:
[O-][N+](=O)c1ccc(Cn2ccc(OCc3ccccc3)cc2=O)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: