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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50326347
Substrate
n/a
Meas. Tech.
ChEMBL_657398 (CHEMBL1246374)
IC50
4260±n/a nM
Citation
 Chimenti, F; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Carradori, S; Yáñez, M; Orallo, F; Sanna, ML; Gallinella, B; Cirilli, R Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines. J Med Chem 53:6516-20 (2010) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50326347
Synonyms:
(R)-4-(4-methoxyphenyl)-2-(2-(3-methylcyclohexylidene)hydrazinyl)thiazole | CHEMBL1243125
Type:
Small organic molecule
Emp. Form.:
C17H21N3OS
Mol. Mass.:
315.433
SMILES:
COc1ccc(cc1)-c1csc(NN=C2CCC[C@@H](C)C2)n1 |r,w:13.13|
Structure:
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