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Target
Protein-tyrosine-phosphatase
Ligand
BDBM50326497
Substrate
n/a
Meas. Tech.
ChEMBL_658096 (CHEMBL1249161)
IC50
50±n/a nM
Citation
 Comeau, AB; Critton, DA; Page, R; Seto, CT A focused library of protein tyrosine phosphatase inhibitors. J Med Chem 53:6768-72 (2010) [PubMed]  Article 
Target
Name:
Protein-tyrosine-phosphatase
Synonyms:
Secreted effector protein | Secreted protein-tyrosine phosphatase
Type:
PROTEIN
Mol. Mass.:
50881.86
Organism:
Yersinia pestis
Description:
ChEMBL_810616
Residue:
468
Sequence:
MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANVVLTQEDTAKLLQSTVKHNLNNYDLRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSALHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVGDDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
  
Inhibitor
Name:
BDBM50326497
Synonyms:
4, 4'-[[2-[[(4-(4-Trifluoromethylthio)phenoxyphenyl)amino]carbonyl]-1, 4-phenylene]bis(methyleneoxy)]bis[alpha-oxobenzeneacetic acid] | CHEMBL1240789
Type:
Small organic molecule
Emp. Form.:
C38H26F3NO10S
Mol. Mass.:
745.674
SMILES:
OC(=O)C(=O)c1ccc(OCc2ccc(COc3ccc(cc3)C(=O)C(O)=O)c(c2)C(=O)Nc2ccc(Oc3ccc(SC(F)(F)F)cc3)cc2)cc1
Structure:
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