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Target
Ecdysone receptor
Ligand
BDBM50326777
Substrate
n/a
Meas. Tech.
ChEMBL_661762 (CHEMBL1251995)
IC50
5500±n/a nM
Citation
 Birru, W; Fernley, RT; Graham, LD; Grusovin, J; Hill, RJ; Hofmann, A; Howell, L; James, PJ; Jarvis, KE; Johnson, WM; Jones, DA; Leitner, C; Liepa, AJ; Lovrecz, GO; Lu, L; Nearn, RH; O'Driscoll, BJ; Phan, T; Pollard, M; Turner, KA; Winkler, DA Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors. Bioorg Med Chem 18:5647-60 (2010) [PubMed]  Article 
Target
Name:
Ecdysone receptor
Synonyms:
20-hydroxy-ecdysone receptor | 20E receptor | ECR_LUCCU | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1
Type:
PROTEIN
Mol. Mass.:
82587.92
Organism:
Lucilia cuprina
Description:
ChEMBL_661762
Residue:
757
Sequence:
MMKRRWSNNGGFAALKMLEESSSEVTSSSNGLVLSSDINMSPSSLDSPVYGDQEMWLCNDSASYNNSHQHSVITSLQGCTSSLPAQTTIIPLSALPNSNNASLNNQNQNYQNGNSMNTNLSVNTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHTNGHMGIGGGGGGLSVNINGPNIVSNAQQLNSLQASQNGQVIHANIGIHSIISNGLNHHHHHHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTSDASDVKKIKKGPAPRLQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKIQTSVCATEIKKEILDLMTCEPPSHPTCPLLPEDILAKCQARNIPPLSYNQLAVIYKLIWYQDGYEQPSEEDLKRIMSSPDENESQHDASFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHNSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMYSMKVDNVEYALLTAIVIFSDRPGLEEAELVEAIQSYYIDTLRIYILNRHCGDPMSLVFFAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHIQATQAEKAAQEAQATTSAISAAATSSSSINTSMATSSSSSLSPSAASTPNGGAVDYVGTDMSMSLVQSDNA
  
Inhibitor
Name:
BDBM50326777
Synonyms:
(2beta,3beta,5beta,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one | 20-hydroxyecdysone | CHEMBL224128
Type:
Small organic molecule
Emp. Form.:
C27H44O7
Mol. Mass.:
480.6341
SMILES:
CC(C)(O)CC[C@@H](O)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C |r,t:16|
Structure:
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