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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50326789
Substrate
n/a
Meas. Tech.
ChEMBL_661769 (CHEMBL1252002)
IC50
223000±n/a nM
Citation
 Huhtiniemi, T; Suuronen, T; Lahtela-Kakkonen, M; Bruijn, T; Jääskeläinen, S; Poso, A; Salminen, A; Leppänen, J; Jarho, E N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2. Bioorg Med Chem 18:5616-25 (2010) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50326789
Synonyms:
(S)-2-((S)-6-Acetamido-2-((S)-2-acetamidopropanamido)hexanamido)propanoic acid | CHEMBL1254124
Type:
Small organic molecule
Emp. Form.:
C16H28N4O6
Mol. Mass.:
372.4167
SMILES:
C[C@H](NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](C)NC(C)=O)C(O)=O |r|
Structure:
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