Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50327604
Substrate
n/a
Meas. Tech.
ChEMBL_664672 (CHEMBL1260558)
Ki
4.47±n/a nM
Citation
 Favor, DA; Powers, JJ; White, AD; Fitzgerald, LW; Groppi, V; Serpa, KA 6-Alkoxyisoindolin-1-one based dopamine D2 partial agonists as potential antipsychotics. Bioorg Med Chem Lett 20:5666-9 (2010) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50327604
Synonyms:
6-(3-(4-(chroman-8-yl)piperazin-1-yl)propoxy)isoindolin-1-one | CHEMBL1257734
Type:
Small organic molecule
Emp. Form.:
C24H29N3O3
Mol. Mass.:
407.5054
SMILES:
O=C1NCc2ccc(OCCCN3CCN(CC3)c3cccc4CCCOc34)cc12
Structure:
Search PDB for entries with ligand similarity: