Reaction Details Report a problem with these data
Target
Beta-3 adrenergic receptor
Ligand
BDBM50328294
Substrate
n/a
Meas. Tech.
ChEMBL_665493 (CHEMBL1261324)
Ki
11±n/a nM
Citation
 Tasler, S; Baumgartner, R; Ammendola, A; Schachtner, J; Wieber, T; Blisse, M; Rath, S; Zaja, M; Klahn, P; Quotschalla, U; Ney, P Thienopyrimidines asß3-adrenoceptor agonists: hit-to-lead optimization. Bioorg Med Chem Lett 20:6108-15 (2010) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50328294
Synonyms:
1-phenoxy-3-(1-(5-(thiophen-2-yl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol | CHEMBL1258025
Type:
Small organic molecule
Emp. Form.:
C24H26N4O2S2
Mol. Mass.:
466.619
SMILES:
OC(CNC1CCN(CC1)c1ncnc2scc(-c3cccs3)c12)COc1ccccc1
Structure:
Search PDB for entries with ligand similarity: