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Target
Aurora kinase B
Ligand
BDBM50328437
Substrate
n/a
Meas. Tech.
ChEMBL_665546 (CHEMBL1261377)
IC50
10540±n/a nM
Citation
 Bouloc, N; Large, JM; Kosmopoulou, M; Sun, C; Faisal, A; Matteucci, M; Reynisson, J; Brown, N; Atrash, B; Blagg, J; McDonald, E; Linardopoulos, S; Bayliss, R; Bavetsias, V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett 20:5988-93 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50328437
Synonyms:
CHEMBL1230687 | N-(3-(3-chloro-8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-6-yl)benzyl)methanesulfonamide | N-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H25ClN6O3S
Mol. Mass.:
513.012
SMILES:
CS(=O)(=O)NCc1cccc(c1)-c1cn2c(Cl)cnc2c(Nc2ccc(cc2)N2CCOCC2)n1
Structure:
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