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Target
Aurora kinase A
Ligand
BDBM50328430
Substrate
n/a
Meas. Tech.
ChEMBL_665540 (CHEMBL1261371)
IC50
7900±n/a nM
Citation
 Bouloc, N; Large, JM; Kosmopoulou, M; Sun, C; Faisal, A; Matteucci, M; Reynisson, J; Brown, N; Atrash, B; Blagg, J; McDonald, E; Linardopoulos, S; Bayliss, R; Bavetsias, V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bioorg Med Chem Lett 20:5988-93 (2010) [PubMed]  Article 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50328430
Synonyms:
1-(4-methoxyphenyl)-3-(3-(8-(4-methoxyphenylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea | CHEMBL1258267
Type:
Small organic molecule
Emp. Form.:
C27H24N6O3
Mol. Mass.:
480.5179
SMILES:
COc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(Nc3ccc(OC)cc3)n2)cc1
Structure:
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