Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50328456
Substrate
n/a
Meas. Tech.
ChEMBL_665574 (CHEMBL1261458)
Ki
2400±n/a nM
Citation
 Skultety, M; Hübner, H; Löber, S; Gmeiner, P Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. J Med Chem 53:7219-28 (2010) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DRD1 | DRD1_PIG | Dopamine D1 receptor
Type:
PROTEIN
Mol. Mass.:
49269.92
Organism:
Sus scrofa
Description:
ChEMBL_1460140
Residue:
446
Sequence:
MRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50328456
Synonyms:
CHEMBL1258383 | N-[4-[4-(2,5-Dimethylphenyl)piperazin-1-yl]butyl]benzo[b]thiophenyl-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H31N3OS
Mol. Mass.:
421.598
SMILES:
Cc1ccc(C)c(c1)N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1
Structure:
Search PDB for entries with ligand similarity: