Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50328445
Substrate
n/a
Meas. Tech.
ChEMBL_665577 (CHEMBL1261461)
Ki
17±n/a nM
Citation
 Skultety, M; Hübner, H; Löber, S; Gmeiner, P Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. J Med Chem 53:7219-28 (2010) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50328445
Synonyms:
4-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-1-([2.2]paracyclophan-4-yl)butan-1-one | CHEMBL1257810
Type:
Small organic molecule
Emp. Form.:
C31H34ClNO2
Mol. Mass.:
488.06
SMILES:
OC1(CCN(CCCC(=O)c2cc3CCc4ccc(CCc2cc3)cc4)CC1)c1ccc(Cl)cc1
Structure:
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