Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50328637
Substrate
n/a
Meas. Tech.
ChEMBL_665768 (CHEMBL1259259)
Ki
22000±n/a nM
Citation
 Bollinger, S; Hübner, H; Heinemann, FW; Meyer, K; Gmeiner, P Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists. J Med Chem 53:7167-79 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52679.13
Organism:
PIG
Description:
5-HT2 0 0::P50129
Residue:
470
Sequence:
MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50328637
Synonyms:
CHEMBL1259241 | benzo[b]thiophen-3-yl(4-fluoro-4-(((5-methylpyridin-2-yl)methylamino)methyl)piperidin-1-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C22H24FN3OS
Mol. Mass.:
397.509
SMILES:
Cc1ccc(CNCC2(F)CCN(CC2)C(=O)c2csc3ccccc23)nc1
Structure:
Search PDB for entries with ligand similarity: