Target
Renin
Ligand
BDBM50329014
Substrate
n/a
Meas. Tech.
ChEMBL_674153 (CHEMBL1274250)
IC50
130±n/a nM
Citation
 Scheiper, BMatter, HSteinhagen, HStilz, UBöcskei, ZFleury, VMcCort, G Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg Med Chem Lett 20:6268-72 (2010) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50329014
Synonyms:
2-(2-(5-fluoro-2-methylphenoxy)-1-phenyl-3-(piperazine-1-carbonyl)-1H-indol-6-yloxy)acetic acid | CHEMBL1270180
Type:
Small organic molecule
Emp. Form.:
C28H26FN3O5
Mol. Mass.:
503.5215
SMILES:
Cc1ccc(F)cc1Oc1c(C(=O)N2CCNCC2)c2ccc(OCC(O)=O)cc2n1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: