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Target
Renin
Ligand
BDBM50329030
Substrate
n/a
Meas. Tech.
ChEMBL_674153 (CHEMBL1274250)
IC50
1350±n/a nM
Citation
 Scheiper, B; Matter, H; Steinhagen, H; Stilz, U; Böcskei, Z; Fleury, V; McCort, G Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors. Bioorg Med Chem Lett 20:6268-72 (2010) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50329030
Synonyms:
(2-(5-fluoro-2-methylphenoxy)-5-methoxy-1-phenyl-1H-indol-3-yl)(piperazin-1-yl)methanone | CHEMBL1269856
Type:
Small organic molecule
Emp. Form.:
C27H26FN3O3
Mol. Mass.:
459.512
SMILES:
COc1ccc2n(c(Oc3cc(F)ccc3C)c(C(=O)N3CCNCC3)c2c1)-c1ccccc1
Structure:
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