Reaction Details Report a problem with these data
Target
Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM50329167
Substrate
n/a
Meas. Tech.
ChEMBL_674428 (CHEMBL1274757)
Ki
2.2±n/a nM
Citation
 Wood, MR; Schirripa, KM; Kim, JJ; Bednar, RA; Fay, JF; Bruno, JG; Moore, EL; Mosser, SD; Roller, S; Salvatore, CA; Vacca, JP; Selnick, HG Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality. Bioorg Med Chem Lett 20:6827-30 (2010) [PubMed]  Article 
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52980.45
Organism:
Homo sapiens (Human)
Description:
Q16602
Residue:
461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
  
Inhibitor
Name:
BDBM50329167
Synonyms:
CHEMBL1269977 | N-benzyl-N-((3'-methyl-2',5'-dioxo-6,8-dihydrospiro[cyclopenta[g]quinoline-7,4'-imidazolidine]-2-yl)methyl)pivalamide
Type:
Small organic molecule
Emp. Form.:
C28H30N4O3
Mol. Mass.:
470.5628
SMILES:
CN1C(=O)NC(=O)C11Cc2cc3ccc(CN(Cc4ccccc4)C(=O)C(C)(C)C)nc3cc2C1
Structure:
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