Reaction Details Report a problem with these data
Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Ligand
BDBM50329257
Substrate
n/a
Meas. Tech.
ChEMBL_675154 (CHEMBL1273011)
Ki
4800±n/a nM
Citation
 Tasdemir, D; Sanabria, D; Lauinger, IL; Tarun, A; Herman, R; Perozzo, R; Zloh, M; Kappe, SH; Brun, R; Carballeira, NM 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem 18:7475-85 (2010) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Synonyms:
Fatty acid synthase
Type:
PROTEIN
Mol. Mass.:
26222.50
Organism:
Plasmodium falciparum
Description:
ChEMBL_983601
Residue:
230
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
  
Inhibitor
Name:
BDBM50329257
Synonyms:
2-Hexadecynoic acid | CHEMBL1269411
Type:
Small organic molecule
Emp. Form.:
C17H30O2
Mol. Mass.:
266.4189
SMILES:
CCCCCCCCCCCCCCC#CC(O)=O
Structure:
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