Target
Apoptosis regulator Bcl-2
Ligand
BDBM50329372
Substrate
n/a
Meas. Tech.
ChEMBL_675630 (CHEMBL1273938)
Kd
250000±n/a nM
Citation
 Petros, AMHuth, JROost, TPark, CMDing, HWang, XZhang, HNimmer, PMendoza, RSun, CMack, JWalter, KDorwin, SGramling, ELadror, URosenberg, SHElmore, SWFesik, SWHajduk, PJ Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett 20:6587-91 (2010) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50329372
Synonyms:
(S)-2-amino-1-(2-chloro-4-fluorophenyl)-1-phenylethanol | CHEMBL1269480
Type:
Small organic molecule
Emp. Form.:
C14H13ClFNO
Mol. Mass.:
265.711
SMILES:
NCC(O)(c1ccccc1)c1ccc(F)cc1Cl
Structure:
Search PDB for entries with ligand similarity: