Reaction Details Report a problem with these data
Target
Proteinase-activated receptor 2
Ligand
BDBM50329494
Substrate
n/a
Meas. Tech.
ChEMBL_674259 (CHEMBL1274356)
EC50
1995±n/a nM
Citation
 Barry, GD; Suen, JY; Le, GT; Cotterell, A; Reid, RC; Fairlie, DP Novel agonists and antagonists for human protease activated receptor 2. J Med Chem 53:7428-40 (2010) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2RL1 | GPR11 | PAR2 | PAR2_HUMAN
Type:
PROTEIN
Mol. Mass.:
44152.54
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1497756
Residue:
397
Sequence:
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
  
Inhibitor
Name:
BDBM50329494
Synonyms:
5-isoxazoyl-Cha-Ile-(3-aminophenyl)-(4-[aminomethyl]piperidin-1-yl)methanone | CHEMBL1269139
Type:
Small organic molecule
Emp. Form.:
C32H46N6O5
Mol. Mass.:
594.7448
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)c1ccno1)C(=O)Nc1cccc(c1)C(=O)N1CCC(CN)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: