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Target
Squalene synthase
Ligand
BDBM50329664
Substrate
n/a
Meas. Tech.
ChEMBL_675491 (CHEMBL1273704)
IC50
155000±n/a nM
Citation
 Kourounakis, AP; Matralis, AN; Nikitakis, A Design of more potent squalene synthase inhibitors with multiple activities. Bioorg Med Chem 18:7402-12 (2010) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50329664
Synonyms:
2-(6-Methoxy-2-naphthalene)-4-methylmorpholin-2-olhydrobromide | CHEMBL1270446
Type:
Small organic molecule
Emp. Form.:
C16H19NO3
Mol. Mass.:
273.327
SMILES:
COc1ccc2cc(ccc2c1)C1(O)CN(C)CCO1
Structure:
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