Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50329678
Substrate
n/a
Meas. Tech.
ChEMBL_675499 (CHEMBL1273712)
Ki
35±n/a nM
Citation
 Lacivita, E; Masotti, AC; Jafurulla, M; Saxena, R; Rangaraj, N; Chattopadhyay, A; Colabufo, NA; Berardi, F; Perrone, R; Leopoldo, M Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors. Bioorg Med Chem Lett 20:6628-32 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50329678
Synonyms:
2-(2-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)vinyl)-1-(6-(3-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)phenoxy)-6-oxohexyl)-3,3-dimethyl-3H-indolium bromide | CHEMBL1269290
Type:
Small organic molecule
Emp. Form.:
C50H59N4O5
Mol. Mass.:
796.0267
SMILES:
CCN(CC)c1ccc2cc(\C=C\C3=[N+](CCCCCC(=O)Oc4cccc(CCN5CCN(CC5)c5ccccc5OC)c4)c4ccccc4C3(C)C)c(=O)oc2c1 |c:13|
Structure:
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