Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50329679
Substrate
n/a
Meas. Tech.
ChEMBL_675499 (CHEMBL1273712)
Ki
65.8±n/a nM
Citation
 Lacivita, E; Masotti, AC; Jafurulla, M; Saxena, R; Rangaraj, N; Chattopadhyay, A; Colabufo, NA; Berardi, F; Perrone, R; Leopoldo, M Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors. Bioorg Med Chem Lett 20:6628-32 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50329679
Synonyms:
CHEMBL1269291 | sodium 4-(2-(2-(3-(2-(3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indolium-2-yl)vinyl)-2-(4-(5-(4-(2-methoxyphenyl)piperazin-1-yl)pentylcarbamoyl)phenylthio)cyclohex-2-enylidene)ethylidene)-3,3-dimethylindolin-1-yl)butane-1-sulfonate chloride
Type:
Small organic molecule
Emp. Form.:
C61H76N5O8S3
Mol. Mass.:
1103.48
SMILES:
[#6]-[#8]-c1ccccc1-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-c2ccc(cc2)\[S+]=[#6]2\[#6](\[#6]-[#6]-[#6]\[#6]\2=[#6]/[#6]=[#6]2/[#7](-[#6]-[#6]-[#6]-[#6]S([#8-])(=O)=O)-c3ccccc3C2([#6])[#6])=[#6]\[#6]=[#6]2\[#7](-[#6]-[#6]-[#6]-[#6]S([#8-])(=O)=O)-c3ccccc3C2([#6])[#6])-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity: