Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50330389
Substrate
n/a
Meas. Tech.
ChEMBL_684503 (CHEMBL1287512)
Ki
75000±n/a nM
Citation
 Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50330389
Synonyms:
3-((2-(l-Prolinol)-1-yl)-ethyl)uracil | CHEMBL1275721
Type:
Small organic molecule
Emp. Form.:
C11H17N3O3
Mol. Mass.:
239.271
SMILES:
OC[C@@H]1CCCN1CCn1c(=O)cc[nH]c1=O |r|
Structure:
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