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Target
Purine nucleoside phosphorylase
Ligand
BDBM50330392
Substrate
n/a
Meas. Tech.
ChEMBL_684502 (CHEMBL1287511)
Kd
5.5±n/a nM
Citation
 Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50330392
Synonyms:
7-(pyrrolidin-1-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL1275660 | Immucillins, 15
Type:
Small organic molecule
Emp. Form.:
C11H14N4O
Mol. Mass.:
218.2551
SMILES:
O=c1[nH]cnc2c(CN3CCCC3)c[nH]c12
Structure:
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