Reaction Details Report a problem with these data
Target
Uridine phosphorylase 1
Ligand
BDBM50078082
Substrate
n/a
Meas. Tech.
ChEMBL_684504 (CHEMBL1287513)
Ki
2300±n/a nM
Citation
 Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase)
Type:
Enzyme
Mol. Mass.:
33939.54
Organism:
Homo sapiens (Human)
Description:
Q16831
Residue:
310
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
  
Inhibitor
Name:
BDBM50078082
Synonyms:
5-(3-Benzyloxy-benzyl)-pyrimidine-2,4,6-trione | CHEMBL37519
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4
Mol. Mass.:
324.3306
SMILES:
Oc1[nH]c(=O)[nH]c(=O)c1Cc1cccc(OCc2ccccc2)c1
Structure:
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