Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50330396
Substrate
n/a
Meas. Tech.
ChEMBL_684503 (CHEMBL1287512)
Ki
136000±n/a nM
Citation
 Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50330396
Synonyms:
1-((3-(l-Prolinol)-1-yl)-propyl)uracil | CHEMBL1275701
Type:
Small organic molecule
Emp. Form.:
C12H19N3O3
Mol. Mass.:
253.2976
SMILES:
OC[C@@H]1CCCN1CCCn1ccc(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: