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Target
Glutamate receptor 4
Ligand
BDBM50094008
Substrate
n/a
Meas. Tech.
ChEMBL_684653 (CHEMBL1285620)
EC50
19600±n/a nM
Citation
 Grove, SJ; Jamieson, C; Maclean, JK; Morrow, JA; Rankovic, Z Positive allosteric modulators of thea-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. J Med Chem 53:7271-9 (2010) [PubMed]  Article 
Target
Name:
Glutamate receptor 4
Synonyms:
GLUR4 | GRIA4 | GRIA4_HUMAN | Glutamate receptor AMPA 3/4 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 4
Type:
PROTEIN
Mol. Mass.:
100881.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468628
Residue:
902
Sequence:
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
  
Inhibitor
Name:
BDBM50094008
Synonyms:
CHEMBL337047 | N-[2-(2'-Fluoro-biphenyl-4-yl)-propyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C16H18FNO2S
Mol. Mass.:
307.383
SMILES:
CC(CNS(C)(=O)=O)c1ccc(cc1)-c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: